CHANDIGARH, 31.01.26-Doctors at Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, have reported a major breakthrough in the treatment of aluminum phosphide, commonly known as Celphos, one of the deadliest forms of poisoning seen in India. The study, conducted in the Department of Internal Medicine at PGIMER, is the first clinical study to demonstrate the effectiveness of intravenous lipid emulsion as a novel life-saving therapy in this otherwise highly fatal condition.
The important findings have been published in the internationally reputed journal *European Review of Medical and Pharmacological Sciences* , bringing global recognition to research addressing a major public-health problem affecting North India.
The study was carried out under the guidance of *Prof. Sanjay Jain, Dean (Academics), Professor and Head of the Department of Internal Medicine, PGIMER,* whose clinical leadership in emergency care played a crucial role in the management of these critically ill patients. The research was funded by the Medical Education and Research Cell (MERC), PGIMER, underlining the institute’s strong institutional support for clinically relevant and socially impactful research.
This randomized clinical study was led by *Dr Mandip Singh Bhatia, Associate Professor of Internal Medicine,* PGIMER, who served as the primary investigator of the project. Dr Saurabh Chandrabhan Sharda was the co-investigator, along with other authors from the Department of Internal Medicine, PGIMER, Chandigarh.
The results of the study were highly encouraging. Patients who received intravenous lipid emulsion in addition to standard medical treatment showed a marked reduction in mortality, along with faster correction of severe metabolic acidosis, improved hemodynamic stability, and better outcomes in critically ill patients, including those presenting with shock and cardiac complications. The findings clearly demonstrate that early administration of this therapy can significantly alter the clinical course of aluminum phosphide poisoning.
A major advantage of this novel treatment is its practicality.
This important research once again highlights PGIMER’s strong commitment to research focused on local diseases and local populations. By generating high-quality scientific evidence that directly benefits farming and rural communities, PGIMER continues to strengthen its role as a national leader in patient-centred research and innovation.